L-threonine, L-thréonine, Thréonine, Treonina.
Threonine is an amino acid. Amino acids are the building blocks the body uses to make proteins.
Threonine is used to treat various nervous system disorders including spinal spasticity, multiple sclerosis, familial spastic paraparesis, and amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease).
Threonine is changed in the body to a chemical called glycine. Glycine works in the brain to reduce constant and unwanted muscle contractions (spasticity).
Possibly Effective for:
Spinal spasticity, a movement disorder caused by spinal cord damage. Taking 6 grams of threonine daily seems to modestly decrease muscle contractions.
Possibly Ineffective for:
Amyotrophic lateral sclerosis (Lou Gehrig’s disease). Taking 2 grams to 4 grams of threonine daily for up to 12 months does not seem to slow the progression of ALS or reduce symptoms. There is also some evidence that threonine might actually worsen lung function in these patients.
Insufficient Evidence for:
Familial spastic paraparesis, a hereditary disorder. Developing evidence suggests that taking 4.5 grams to 6 grams of threonine daily might improve some symptoms. But the improvement does not seem to be very significant.
More evidence is needed to rate the effectiveness of threonine for these uses.
Threonine seems to be safe when doses of 2 grams to 4 grams daily are taken for up to 12 months. Some people experience minor side effects such as stomach upset, headache, nausea, and skin rash.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of threonine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Amyotrophic lateral sclerosis (Lou Gehrig’s disease): There is some concern that threonine might decrease lung function in patients with ALS. In one study, ALS patients taking 4 grams of threonine per day had significantly reduced lung function compared to patients who did not receive threonine. But more evidence is needed to determine if threonine was actually at fault.
Major Interaction. Do not take this combination:
Medications used for Alzheimer’s disease (NMDA antagonists) interacts with THREONINE
There is some concern that threonine might decrease how well a medication used for Alzheimer’s disease works. This medication is called memantine (Namenda).